Synthesis and antimicrobial evaluation of substituted benzimidazolyl fluoroquinolones under conventional and microwave irradiation conditions

Abstract

New ciprofloxacin analogs 3a–i were prepared using a conventional methodology and with the help of a microwave irradiation technique. The structures of the synthesized compounds were established on the basis of spectral and analytical data. The antimicrobial activities of newly synthesized compounds were evaluated against a number of microorganisms by using ciprofloxacin as reference. Many of the evaluated compounds exhibit remarkable activities against Gram positive organisms such as Staphylococcus aureus, Streptococci, Bacillus spp., Gram negative organisms such as Escherichia coli, Klebsiella Pneumoniae, Pseudomonas aeruginosa, Salmonella spp., Salmonella typhi and antifungal activity against Candida albicans. Among these, compounds 3a, 3b and 3i exhibit excellent antibacterial activity and products 3c and 3f show very good antifungal activity.