Increased Infarct Wall Thickness by a Bio-Inert Material Is Insufficient to Prevent Negative Left Ventricular Remodeling after Myocardial Infarction
Open Access
- 23 June 2011
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 6 (6), e21571
- https://doi.org/10.1371/journal.pone.0021571
Abstract
Several injectable materials have been shown to preserve or improve cardiac function as well as prevent or slow left ventricular (LV) remodeling post-myocardial infarction (MI). However, it is unclear as to whether it is the structural support or the bioactivity of these polymers that lead to beneficial effects. Herein, we examine how passive structural enhancement of the LV wall by an increase in wall thickness affects cardiac function post-MI using a bio-inert, non-degradable synthetic polymer in an effort to better understand the mechanisms by which injectable materials affect LV remodeling. Poly(ethylene glycol) (PEG) gels of storage modulus G′ = 0.5±0.1 kPa were injected and polymerized in situ one week after total occlusion of the left coronary artery in female Sprague Dawley rats. The animals were imaged using magnetic resonance imaging (MRI) at 7±1 day(s) post-MI as a baseline and again post-injection 49±4 days after MI. Infarct wall thickness was statistically increased in PEG gel injected vs. control animals (pp<0.01). The cellular response to injection was also similar in both groups. The results of this study demonstrate that passive structural reinforcement alone was insufficient to prevent post-MI remodeling, suggesting that bioactivity and/or cell infiltration due to degradation of injectable materials are likely playing a key role in the preservation of cardiac function, thus providing a deeper understanding of the influencing properties of biomaterials necessary to prevent post-MI negative remodeling.Keywords
This publication has 54 references indexed in Scilit:
- Differential efficacy of gels derived from small intestinal submucosa as an injectable biomaterial for myocardial infarct repairBiomaterials, 2010
- Functional Improvement of Infarcted Heart by Co-Injection of Embryonic Stem Cells with Temperature-Responsive Chitosan HydrogelTissue Engineering, Part A, 2009
- Biomaterials for the Treatment of Myocardial InfarctionJournal of the American College of Cardiology, 2006
- Artificial Matrix Helps Neonatal Cardiomyocytes Restore Injured Myocardium in RatsArtificial Organs, 2006
- Thickening of the Infarcted Wall by Collagen Injection Improves Left Ventricular Function in Rats: A Novel Approach to Preserve Cardiac Function After Myocardial InfarctionJournal of the American College of Cardiology, 2005
- Fibrin Glue Alone and Skeletal Myoblasts in a Fibrin Scaffold Preserve Cardiac Function after Myocardial InfarctionTissue Engineering, 2004
- Left Ventricular Remodeling After Myocardial InfarctionCirculation, 2000
- Regulation of collagen degradation in the rat myocardium after infarctionJournal of Molecular and Cellular Cardiology, 1995
- LEFT VENTRICULAR REMODELING AFTER ACUTE MYOCARDIAL INFARCTIONAnnual Review of Medicine, 1995
- Role of collagen in acute myocardial infarct expansion.Circulation, 1991