A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer
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Open Access
- 6 January 2016
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 8 (320), 320ra4
- https://doi.org/10.1126/scitranslmed.aad0293
Abstract
A first-in-human phase 1 clinical trial of the PEGylated protease-activated fluorescent probe, LUM015, enables tumor imaging at a safe and tolerable dose in humans.Keywords
Funding Information
- American Society of Clinical Oncology Advanced Clinical Research Award
- NIH (#T32GM007171)
- National Cancer Institute Small Business Innovation Research (#1U43CA165024)
- National Center for Advancing Translational Science (#UL1TR001117)
- Duke Comprehensive Cancer Center Support (5P30-CA-014236-38)
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