Cutaneous lymphoproliferative disorders: strategies for molecular biological analysis and their major findings
- 1 July 1992
- journal article
- review article
- Published by Springer Science and Business Media LLC in Springer Seminars in Immunopathology
- Vol. 13 (3-4), 387-399
- https://doi.org/10.1007/bf00200536
Abstract
This article focuses on the principal molecular biological methods that have been devised to study cutaneous lymphoid infiltrates. These methods involve analysis of antigen receptor gene rearrangements, chromosomal translocations and proviral integration using Southern blot analysis and gene amplification techniques. The major findings are discussed that pertain to early diagnosis, staging, disease monitoring, the development of new immunopathological assays and the detection of tumor-associated retroviruses.Keywords
This publication has 19 references indexed in Scilit:
- Diversity of T-cell antigen receptor variable genes used by mycosis fungoides cells.1992
- Sensitive detection of clonal antigen receptor gene rearrangements for the diagnosis and monitoring of lymphoid neoplasms by a polymerase chain reaction-mediated ribonuclease protection assay.1991
- Quantitation of T-cell DNA in cutaneous lymphoid infiltrates.1991
- Examination of HTLV-I Integration in the Skin Lesions of Various Types of Adult T-Cell Leukemia (ATL): Independence of Cutaneous-Type ATL Confirmed by Southern Blot AnalysisJournal of Investigative Dermatology, 1991
- Rapid, nonradioactive detection of clonal T-cell receptor gene rearrangements in lymphoid neoplasms.Proceedings of the National Academy of Sciences of the United States of America, 1990
- Anti-V Region Antibodies as “Almost Clonotypic” Reagents for the Study of Cutaneous T Cell Lymphomas and LeukemiasJournal of Investigative Dermatology, 1990
- CUTANEOUS T-CELL LYMPHOMA-CELLS EMPLOY A RESTRICTED RANGE OF T-CELL ANTIGEN RECEPTOR VARIABLE REGION GENES1990
- Detection of Clonal T-Cell Receptor Gene Rearrangements in the Peripheral Blood of Patients with Mycosis Fungoides/Sezary SyndromeJournal of Investigative Dermatology, 1989
- HTLV-V: a New Human Retrovirus Isolated in a Tac-Negative T Cell Lymphoma/LeukemiaScience, 1987
- ANTIBODIES TO T CELL ANTIGEN RECEPTOR BETA CHAIN FAMILIES DETECT MONOCLONAL T CELL PROLIFERATIONThe Lancet, 1986