Kinetic Evidence for the Existence and Mechanism of Formation of a Barrel Stave Structure from Pore-Forming Dendrimers
- 28 October 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (46), 13984-13987
- https://doi.org/10.1021/ja036390h
Abstract
A dendritic approach to the construction of a homologous series of pore-forming amphiphiles has been developed, based on the use of spermidine, spermine, lysine, and cholic acid. A kinetic analysis of Na+ transport across bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine by three dendritic amphiphiles has provided the strongest evidence to date for a barrel stave structure.Keywords
This publication has 9 references indexed in Scilit:
- Selective Transport of ATP across a Phospholipid Bilayer by a Molecular UmbrellaJournal of the American Chemical Society, 2003
- Ion Conductors Derived from Biogenic Amines, Bile Acids, and Amino AcidsBioconjugate Chemistry, 2002
- Ion Conductors Derived from Cholic Acid and Spermine: Importance of Facial Hydrophilicity on Na+ Transport and Membrane SelectivityJournal of the American Chemical Society, 2001
- An Ion Conductor Derived from Spermine and Cholic AcidJournal of the American Chemical Society, 2000
- Modular Control over the Selectivity of Self-Assembling and Membrane-Spanning Ion ConductorsJournal of the American Chemical Society, 1999
- Amphotericin B Mimics: A Sterol-Based IonophoreJournal of the American Chemical Society, 1994
- BiomembranesPublished by Springer Science and Business Media LLC ,1989
- How do the polyene macrolide antibiotics affect the cellular membrane properties?Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1986
- Single-length and double-length channels formed by nystatin in lipid bilayer membranesThe Journal of Membrane Biology, 1984