Cyanobacteria and Cyanotoxins: From Impacts on Aquatic Ecosystems and Human Health to Anticarcinogenic Effects
Open Access
- 23 October 2013
- Vol. 5 (10), 1896-1917
- https://doi.org/10.3390/toxins5101896
Abstract
Cyanobacteria or blue-green algae are among the pioneer organisms of planet Earth. They developed an efficient photosynthetic capacity and played a significant role in the evolution of the early atmosphere. Essential for the development and evolution of species, they proliferate easily in aquatic environments, primarily due to human activities. Eutrophic environments are conducive to the appearance of cyanobacterial blooms that not only affect water quality, but also produce highly toxic metabolites. Poisoning and serious chronic effects in humans, such as cancer, have been described. On the other hand, many cyanobacterial genera have been studied for their toxins with anticancer potential in human cell lines, generating promising results for future research toward controlling human adenocarcinomas. This review presents the knowledge that has evolved on the topic of toxins produced by cyanobacteria, ranging from their negative impacts to their benefits.Keywords
This publication has 88 references indexed in Scilit:
- Exploring Marine Cyanobacteria for Lead Compounds of Pharmaceutical ImportanceThe Scientific World Journal, 2012
- Biologically active secondary metabolites from marine cyanobacteriaCurrent Opinion in Biotechnology, 2010
- Cylindrocyclophanes with Proteasome Inhibitory Activity from the Cyanobacterium Nostoc sp.Journal of Natural Products, 2010
- Anticancer Drugs from Marine Flora: An OverviewJournal of Oncology, 2010
- Marine natural products as inhibitors of hypoxic signaling in tumorsPhytochemistry Reviews, 2009
- Toxins produced in cyanobacterial water blooms - toxicity and risksInterdisciplinary Toxicology, 2009
- Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine Cyanobacterium Leptolyngbya sp.Journal of the American Chemical Society, 2008
- Allelopathic activity among Cyanobacteria and microalgae isolated from Florida freshwater habitatsFEMS Microbiology Ecology, 2008
- Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majusculaJournal of Natural Products, 2004
- The Hallmarks of CancerCell, 2000