Corneal Biomechanical Properties in Primary Open Angle Glaucoma and Normal Tension Glaucoma
- 1 June 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Glaucoma
- Vol. 17 (4), 259-262
- https://doi.org/10.1097/ijg.0b013e31815c3a93
Abstract
To determine and compare the corneal biomechanical properties between eyes with primary open angle glaucoma (POAG) and eyes with normal tension glaucoma (NTG). Prospective cross-sectional study. Consecutive eligible POAG and NTG patients attending the Glaucoma Clinic had assessment of their corneal biomechanical properties-corneal hysteresis (CH) and corneal resistance factor (CRF)-using the Ocular Response Analyzer by an observer masked to the diagnosis. Exclusion criteria included previous intraocular surgery, corneal pathology, inflammatory connective tissue disease, and refraction of 5-dimensional or over. If both eyes were eligible, then the right eye was used for analysis. The main outcome measures were corneal hysteresis and CRF measurements. Data analysis was performed using the t test and general linear model. Eighty-one patients (80 whites) were analyzed. Forty had NTG, whereas 41 had POAG. Thirty-five were females. There was a statistically significant difference in mean CH (NTG 9.6+/-1.3 mm Hg; POAG 9.0+/-1.4 mm Hg; P=0.01), but not in mean CRF (NTG 9.9+/-1.4; POAG 10.8+/-1.7; P=0.06). The highest recorded Goldmann applanation intraocular pressure (IOP) was statistically significantly associated with lower CH (P=0.01) and higher CRF (P=0.02). There was a small but statistically significant difference in the mean CH between POAG and NTG (CH was higher in NTG). The highest recorded Goldmann applanation IOP was also statistically significantly correlated with lower CH and higher CRF, suggesting that alterations to the corneal biomechanical properties may occur as a result of chronic raised IOP in POAG.Keywords
This publication has 25 references indexed in Scilit:
- Variations in Primary Open-Angle Glaucoma Prevalence by Age, Gender, and Race: A Bayesian Meta-AnalysisInvestigative Ophthalmology & Visual Science, 2006
- Causes of blindness and visual impairment in the West of ScotlandEye, 2004
- Reduction of Intraocular Pressure and Glaucoma ProgressionAmerican Journal of Ophthalmology, 2002
- The Ocular Hypertension Treatment StudyAmerican Journal of Ophthalmology, 2002
- The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deteriorationAmerican Journal of Ophthalmology, 2000
- The rates of blindness and of partial sight registration in glaucoma patientsEye, 2000
- Sources of error with use of Goldmann-type tonometersSurvey of Ophthalmology, 1993
- Prevalence of GlaucomaOphthalmology, 1992
- Blind and partial sight registration in Avon.British Journal of Ophthalmology, 1989
- Recent trends in the registration of blindness and partial sight in Leicestershire.British Journal of Ophthalmology, 1989