Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators
Top Cited Papers
- 15 October 2010
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 330 (6002), 379-385
- https://doi.org/10.1126/science.1195262
Abstract
Environmental temperature cycles are a universal entraining cue for all circadian systems at the organismal level with the exception of homeothermic vertebrates. We report here that resistance to temperature entrainment is a property of the suprachiasmatic nucleus (SCN) network and is not a cell-autonomous property of mammalian clocks. This differential sensitivity to temperature allows the SCN to drive circadian rhythms in body temperature, which can then act as a universal cue for the entrainment of cell-autonomous oscillators throughout the body. Pharmacological experiments show that network interactions in the SCN are required for temperature resistance and that the heat shock pathway is integral to temperature resetting and temperature compensation in mammalian cells. These results suggest that the evolutionarily ancient temperature resetting response can be used in homeothermic animals to enhance internal circadian synchronization.Keywords
This publication has 48 references indexed in Scilit:
- Nonparametric entrainment of the in vitro circadian phosphorylation rhythm of cyanobacterial KaiC by temperature cycleProceedings of the National Academy of Sciences of the United States of America, 2009
- Natural Variation in the Splice Site Strength of a Clock Gene and Species-Specific Thermal AdaptationNeuron, 2008
- cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian PacemakerScience, 2008
- Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factorGenes & Development, 2008
- Development of the mouse suprachiasmatic nucleus: Determination of time of cell origin and spatial arrangements within the nucleusBrain Research, 2007
- PER-TIM Interactions with the Photoreceptor Cryptochrome Mediate Circadian Temperature Responses in DrosophilaPLoS Biology, 2007
- System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver ClockPLoS Biology, 2007
- Temperature Regulates Transcription in the Zebrafish Circadian ClockPLoS Biology, 2005
- MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal OrganizationAnnual Review of Genomics and Human Genetics, 2004
- PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissuesProceedings of the National Academy of Sciences, 2004