Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know
- 1 August 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 10 (8), 806-810
- https://doi.org/10.1038/nm0804-806
Abstract
The field of vaccinology began in ignorance of how protection was instilled in vaccine recipients. Today, a greater knowledge of immunology allows us to better understand what is being stimulated by various vaccines that leads to their protective effects: that is, their correlates of protection. Here we describe what is known about the correlates of protection for existing vaccines against a range of different viral diseases and discuss the correlates of protection against disease during natural infection with HIV-1. We will also discuss why it is important to design phase 3 clinical trials of HIV vaccines to determine the correlates of protection for each individual vaccine.Keywords
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