Mitochondrial uncoupling protein 2 gene transcript levels are elevated in maturating erythroid cells
- 15 February 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (6), 1093-1097
- https://doi.org/10.1016/j.febslet.2007.02.012
Abstract
Mitochondrial uncoupling protein 2 (UCP2) is abundant in developing monocyte/macrophage cells and may affect hematopoiesis by reducing formation of reactive oxygen species. The aims of this study were to further characterize the involvement of UCP2 in hematopoiesis. In situ hybridization in mouse embryos identified UCP2-positive cells in liver and inside primitive blood vessels from 10.5 days of prenatal development. High UCP2 transcript levels were detected in reticulocytes and other maturating erythroid cells in peripheral blood of mice exposed to hypoxia, and in umbilical cord blood of human neonates and peripheral blood of adults. Our results suggest involvement of UCP2 in erythropoiesis.This publication has 19 references indexed in Scilit:
- Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progressionCellular Signalling, 2006
- Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: Identification of novel heme-regulated genesBiochemical and Biophysical Research Communications, 2006
- Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3Cell Metabolism, 2005
- Characterization of the differential expression of uncoupling protein 2 and ROS production in differentiated mouse macrophage-cells (Mm1) and the progenitor cells (M1)Journal of Molecular Histology, 2005
- Starvation-sensitive UCP 3 protein expression in thymus and spleen mitochondriaBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2004
- Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in miceHepatology, 2004
- Bone Marrow Transplantation Reveals the in Vivo Expression of the Mitochondrial Uncoupling Protein 2 in Immune and Nonimmune Cells during InflammationPublished by Elsevier BV ,2003
- Fast Decline of Hematopoiesis and Uncoupling Protein 2 Content in Human Liver after Birth: Location of the Protein in Kupffer CellsPediatric Research, 2001
- High-Altitude TrainingSports Medicine, 1992
- Reticulocyte quantification by flow cytometry, image analysis, and manual countingCytometry, 1992