Protective effect of butylated hydroxytoluene against induction of gastric cancer byN-methyl-N′-nitro-N-nitrosoguanidine in wistar rats
- 15 August 1983
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 32 (2), 253-254
- https://doi.org/10.1002/ijc.2910320218
Abstract
The effects of butylated hydroxytoluene (BHT) on the incidence and histology of gastric cancers induced by oral administration of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG) were investigated in Wistar rats. Oral administration of 1.0% BHT in regular chow pellets during treatment with MNNG for 25 weeks significantly reduced the incidence of gastric cancers in experimental week 40. BHT had no influence on the histological type of adenocarcinomas induced in MNNG‐treated rats. BHT alone induced slight glandular hyperplasia, but not moderate glandular hyperplasia or gastric cancer.This publication has 5 references indexed in Scilit:
- Selective Sex-Related Modification of Diethylnitrosamine-lnduced Carcinogenesis in BALB/c Mice by Concomitant Administration of Butylated Hydroxytoluene2JNCI Journal of the National Cancer Institute, 1978
- Diet and cancerCancer, 1977
- Enhancement of Urethan Tumorigenesis in Mouse Lung by Butylated Hydroxytoluene2JNCI Journal of the National Cancer Institute, 1977
- Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in ratsFood and Cosmetics Toxicology, 1973
- Carcinogen-Induced Chromosomal Breakage Decreased by AntioxidantsProceedings of the National Academy of Sciences of the United States of America, 1973