How I treat infant leukemia
Open Access
- 17 January 2019
- journal article
- review article
- Published by American Society of Hematology in Blood
- Vol. 133 (3), 205-214
- https://doi.org/10.1182/blood-2018-04-785980
Abstract
Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical presentation in a uniquely vulnerable host, its poor response to current therapies, and its fascinating biology. Increasingly, these biological insights are pointing the way towards novel therapeutic approaches. Using representative clinical case presentations, we review the key clinical, pathologic and epidemiologic features of infant leukemia, including the high frequency of KMT2A gene rearrangements. We describe the current approach to risk stratified treatment of infant leukemia in the major international cooperative groups. We highlight recent discoveries that elucidate the molecular biology of infant leukemia and suggest novel targeted therapeutic strategies, including modulation of aberrant epigenetic programs, inhibition of signaling pathways, and immunotherapeutics. Finally, we underscore the need for increased global collaboration to translate these discoveries into improved outcomes.This publication has 98 references indexed in Scilit:
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