The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)
- 16 April 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Genes & Nutrition
- Vol. 6 (3), 261-274
- https://doi.org/10.1007/s12263-011-0218-x
Abstract
The probiotic approach represents a potentially effective and mild alternative strategy for the prevention and treatment of either inflammatory or allergic diseases. Several studies have shown that different bacterial strains can exert their probiotic abilities by influencing the host’s immune system, thereby modulating immune responses. However, the emerging concern regarding safety problems arising from the extensive use of live microbial cells is enhancing the interest in non-viable microorganisms or microbial cell extracts, as they could eliminate shelf-life problems and reduce the risks of microbial translocation and infection. The purpose of this review is to provide an overview of the scientific literature concerning studies in which dead microbial cells or crude microbial cell fractions have been used as health-promoting agents. Particular attention will be given to the modulation of host immune responses. Possible mechanisms determining the effect on the immune system will also be discussed. Finally, in the light of the FAO/WHO definition of probiotics, indicating that the word ‘probiotic’ should be restricted to products that contain live microorganisms, and considering the scientific evidence indicating that inactivated microbes can positively affect human health, we propose the new term ‘paraprobiotic’ to indicate the use of inactivated microbial cells or cell fractions to confer a health benefit to the consumer.Keywords
This publication has 78 references indexed in Scilit:
- Lactobacillus plantarum lipoteichoic acid down-regulated Shigella flexneri peptidoglycan-induced inflammationMolecular Immunology, 2011
- A Dairy Bacterium Displays I n V itro Probiotic Properties for the Pharyngeal Mucosa by Antagonizing Group A Streptococci and Modulating the Immune ResponseInfection and Immunity, 2010
- Genomic Insights into BifidobacteriaMicrobiology and Molecular Biology Reviews, 2010
- Cell Surface of Lactococcus lactis Is Covered by a Protective Polysaccharide PellicleJournal of Biological Chemistry, 2010
- AUF1 is involved in splenic follicular B cell maintenanceBMC Immunology, 2010
- S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functionsProceedings of the National Academy of Sciences of the United States of America, 2008
- Implication of an Outer Surface Lipoprotein in Adhesion of Bifidobacterium bifidum to Caco-2 CellsApplied and Environmental Microbiology, 2008
- Heat-Killed Cells of Lactobacilli Skew the Immune Response Toward T Helper 1 Polarization in Mouse Splenocytes and Dendritic Cell-Treated T CellsJournal of Agricultural and Food Chemistry, 2007
- Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applicationsClinical and Experimental Immunology, 2007
- Screening of Exopolysaccharide-Producing Lactobacillus and Bifidobacterium Strains Isolated from the Human Intestinal MicrobiotaApplied and Environmental Microbiology, 2007