Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain
- 4 April 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 342 (2), 203-208
- https://doi.org/10.1016/0014-5793(94)80501-6
Abstract
Tau protein kinase II (TPKII) was reported previously to be composed of a neuron-rich cdc2-related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2-related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.Keywords
This publication has 36 references indexed in Scilit:
- Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5FEBS Letters, 1993
- A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubuleFEBS Letters, 1993
- Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filamentsFEBS Letters, 1993
- Cyclins and cyclin-dependent kinases: take your partnersTrends in Biochemical Sciences, 1993
- τ Protein Kinase II Is Involved in the Regulation of the Normal Phosphorylation State of τ ProteinJournal of Neurochemistry, 1993
- Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclinsGenomics, 1992
- Sequence identification of 2,375 human brain genesNature, 1992
- A novel brain‐specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr‐Pro kinase (TPK II) from tau protein kinase fractionsFEBS Letters, 1991
- Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeastCell, 1991
- Human D-type cyclinCell, 1991