Neosquamous Epithelium Does Not Typically Arise from Barrett's Epithelium
Open Access
- 15 March 2006
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (6), 1701-1706
- https://doi.org/10.1158/1078-0432.ccr-05-1810
Abstract
Purpose: Neosquamous epithelium (NSE) can arise within Barrett's esophagus as a consequence of medical or surgical acid reduction therapy, as well as after endoscopic ablation. Morphologic studies have suggested that NSE can develop from adjacent squamous epithelium, submucosal gland ducts, or multipotent progenitor cell(s) that can give rise to either squamous or Barrett's epithelium, depending on the luminal environment. The cells responsible for Barrett's epithelium self-renewal are frequently mutated during neoplastic progression. If NSE arises from the same cells that self-renew the Barrett's epithelium, the two tissues should be clonally related and share genetic alterations; if NSE does not originate in the self-renewing Barrett's, NSE and Barrett's esophagus should be genetically independent.Keywords
This publication has 29 references indexed in Scilit:
- Flow cytometric enrichment for respiratory epithelial cells in sputumCytometry, 2004
- International, multicenter, partially blinded, randomised study of the efficacy of photodynamic therapy (PDT) using porfimer sodium (POR) for the ablation of high-grade dysplasia (HGD) in barrett's esophagus (BE): Results of 24-month follow-upGastroenterology, 2003
- Genetic pathways involved in the progression of Barrett's metaplasia to adenocarcinomaBritish Journal of Surgery, 2002
- p53 Mutations in Barrett's esophagus predict poor response to photodynamic therapyGastroenterology, 2001
- Regression of columnar‐lined (Barrett’s) oesophagus with omeprazole 40 mg daily: results of 5 years of continuous therapyAlimentary Pharmacology & Therapeutics, 1999
- The Histopathology of Treated Barrett's EsophagusThe American Journal of Surgical Pathology, 1998
- Regression of columnar lined (Barrett's) oesophagus with continuous omeprazole therapyAlimentary Pharmacology & Therapeutics, 1993
- Sensitive two-stage PCR of p53 genomic DNA exons 5-9.Genome Research, 1993
- Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPaseNature, 1981
- Cell proliferation in three types of Barrett's epitheliumGut, 1980