Methods of Inducing Inflammatory Bowel Disease in Mice

Abstract

Animal models of experimentally induced inflammatory bowel disease (IBD) are useful for understanding more about the mechanistic basis of disease, identifying new targets for therapeutic intervention, and testing novel therapeutic agents. This unit provides detailed protocols for four of the most commonly used mouse models of experimentally induced intestinal inflammation: chemical induction of colitis by dextran sodium sulfate (DSS), hapten-induced colitis via 2,4,6-trinitrobenzene sulfonic acid (TNBS), Helicobacter–induced colitis in mdr1a^−/− mice, and the CD4⁺ CD45RB^hi SCID transfer colitis model. Curr. Protoc. Pharmacol. 47:5.58.1-5.58.37. © 2009 by John Wiley & Sons, Inc.