Two new recently instituted techniques have eliminated the shortcomings associated with computed tomography-guided biopsy procedures. By using the bolus biopsy technique, it has been possible to assess the vascular anatomy and vascularity of abnormalities so that cutting-type needles can be used on a routine basis. In a series of 47 cases, this method was used to select cases for cutting biopsies. In 29 cases in which the cutting biopsy was performed, tissue was successfully recovered in 25 cases. Advantages of large specimens obtained by such large needles are discussed. Secondly, the fourth generation scanning devices permit scanning at low radiation doses that provide slightly noisier but suitable images to perform the biopsy procedures. This eliminates the possibility of objectionably high radiation dose if more than one scan is required.