Ricin B chain converts a non‐cytotoxic antibody‐ricin A chain conjugate into a potent and specific cytotoxic agent
- 28 November 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 164 (1), 17-20
- https://doi.org/10.1016/0014-5793(83)80009-x
Abstract
We report the conversion of a non‐cytotoxic antibody‐ricin A chain conjugate to one displaying specific cytotoxic effects comparable with that of native ricin, by the addition of ricin B chain as a second stage reagent. The results suggest that this conversion is achieved by the association of the added B chain with the A chain of the conjugate, and not through a primary binding of B chain at the cell surface.Keywords
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