Tissue Destruction by Neutrophils
- 9 February 1989
- journal article
- review article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 320 (6), 365-376
- https://doi.org/10.1056/nejm198902093200606
Abstract
WITH increasing frequency, the human neutrophil is being implicated as a mediator of tissue-destructive events in inflammatory diseases ranging from rheumatoid arthritis and myocardial reperfusion injury to respiratory distress syndromes, blistering skin disorders, and ulcerative colitis.1 , 2 In each of these diseases, as well as a variety of other acute inflammatory disorders, important components of these pathologic processes are being linked to the neutrophil's ability to release a complex assortment of agents that can destroy normal cells and dissolve connective tissues. Although these toxins normally defend the host against invading microbes, the neutrophil has little intrinsic ability to differentiate between foreign . . .Keywords
This publication has 67 references indexed in Scilit:
- Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinasesFEBS Letters, 1988
- Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.JCI Insight, 1987
- Neutrophils in Human DiseasesThe New England Journal of Medicine, 1987
- Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.JCI Insight, 1987
- The effect of d-penicillamine on myeloperoxidase: formation of Compound III and inhibition of the chlorinating activityBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987
- Degradation of human glomerular basement membrane by stimulated neutrophils. Activation of a metalloproteinase(s) by reactive oxygen metabolites.JCI Insight, 1987
- Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.JCI Insight, 1984
- Assessment of chlorination by human neutrophilsNature, 1983
- INFECTED WOUNDSThe American Journal of the Medical Sciences, 1918
- STERILISATION BY DAKIN'S SOLUTION AND THE OCCURRENCE OF SECONDARY HqMORRHAGE.The Lancet, 1917