Correlation of Expression of H/LeY/LeBAntigens with Survival in Patients with Carcinoma of the Lung

Abstract

The level of expression of H/Le^y/Le^b antigens is high in various histologic types of lung cancer, a feature that may be related to deletion of A and B blood-group antigens. We evaluated the possibility that expression of this antigen, which can be defined by the monoclonal antibody MIA-15–5, might be of prognostic value, as suggested by our previous observation that MIA-15–5 inhibits tumor-cell motility and metastasis.