What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?
- 15 October 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in Immunologic Research
- Vol. 46 (1-3), 32-44
- https://doi.org/10.1007/s12026-009-8123-8
Abstract
The expression of major histocompatibility complex (MHC) class I molecules on the cell surface is critical for recognition by cytotoxic T lymphocytes (CTL). This recognition event leads to destruction of cells displaying MHC class I—viral peptide complexes or cells displaying MHC class I—mutant peptide complexes. Before they can be transported to the cell surface, MHC class I molecules must associate with their peptide ligand in the endoplasmic reticulum (ER) of the cell. Within the ER, numerous proteins assist in the appropriate assembly and folding of MHC class I molecules. These include the heterodimeric transporter associated with antigen processing (TAP1 and TAP2), the heterodimeric chaperone-oxidoreductase complex of tapasin and ERp57 and the general ER chaperones calreticulin and calnexin. Each of these accessory proteins has a well-defined role in antigen presentation by MHC class I molecules. However, alternate splice forms of MHC class I heavy chains, TAP and tapasin, have been reported suggesting additional complexity to the picture of antigen presentation. Here, we review the importance of these different accessory proteins and the progress in our understanding of alternate splicing in antigen presentation.Keywords
This publication has 116 references indexed in Scilit:
- Differential contribution of TAP and tapasin to HLA class I antigen expressionImmunology, 2008
- A Naturally Occurring Splice Variant of CXCL12/Stromal Cell-Derived Factor 1 Is a Potent Human Immunodeficiency Virus Type 1 Inhibitor with Weak Chemotaxis and Cell Survival ActivitiesJournal of Virology, 2007
- Understanding alternative splicing: towards a cellular codeNature Reviews Molecular Cell Biology, 2005
- Generation of a functional, soluble tapasin protein from an alternatively spliced mRNAGenes & Immunity, 2003
- Distinct Transcriptional Pathways Regulate Basal and Activated Major Histocompatibility Complex Class I ExpressionMolecular and Cellular Biology, 2003
- Major Histocompatibility Complex Class II Transcriptional Platform: Assembly of Nuclear Factor Y and Regulatory Factor X (RFX) on DNA Requires RFX5 DimersMolecular and Cellular Biology, 2002
- Assembly and Antigen-Presenting Function of MHC Class I Molecules in Cells Lacking the ER Chaperone CalreticulinImmunity, 2002
- The Role of ERp57 in Disulfide Bond Formation during the Assembly of Major Histocompatibility Complex Class I in a Synchronized Semipermeabilized Cell Translation SystemPublished by Elsevier BV ,2000
- Calnexin Influences Folding of Human Class I Histocompatibility Proteins but Not Their Assembly with β2-MicroglobulinPublished by Elsevier BV ,1995
- Major Histocompatibility Class I Molecules Can Present Cryptic Translation Products to T-cellsPublished by Elsevier BV ,1995