Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria

Abstract

Recently, we proposed a hypothetical model of coexistence of “Reactive oxygen cycle” with Q cycle and H⁺ cycle in mitochondrial respiratory chain to combine both processes of univalent electron leak for production of superoxide and of proton leak across inner mitochondrial membrane. This review presents a more detailed description of this model and summarizes the supporting experimental evidence obtained.