It has been demonstrated that administration of hepcidin or stimulation of its expression can improve iron overload (IO) by decreasing iron absorption. In this study of a murine model of β-thalassemia intermedia, Kautz et al. showed that they could reduce hepcidin suppression by inhibition of erythroferrone. This Recommendation is of an article referenced in an F1000 Faculty Review also written by Eliezer Rachmilewitz and Eitan Fibach.