Hyaluronate in Morphogenesis: Inhibition of Chondrogenesis In Vitro
Open Access
- 1 June 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 69 (6), 1384-1386
- https://doi.org/10.1073/pnas.69.6.1384
Abstract
Purified hyaluronate, at a concentration as low as 1 ng/ml, blocks the formation of colonies and cartilage nodules in stationary cultures of cells, isolated by treatment with trypsin, from embryonic chick somites and limb buds. This phenomenon in vitro is correlated with sequences of hyaluronate production and hyaluronidase activity during chondrogenesis in embryonic and regenerating tissues in vivo. An hypothesis is proposed in which hyaluronate acts as a regulator or inhibitor of mesenchymal cell aggregation in embryogenesis, its synthesis and removal being part of the mechanism of timing of migration, aggregation, and subsequent differentiation.This publication has 30 references indexed in Scilit:
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