Exosomal miRNAs: Biological Properties and Therapeutic Potential
Open Access
- 1 January 2012
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Genetics
- Vol. 3, 56
- https://doi.org/10.3389/fgene.2012.00056
Abstract
MicroRNAs (miRNAs), small non-coding regulatory RNAs that regulate gene expression at the post-transcriptional level, are master regulators of a wide array of cellular processes. Altered miRNA expression could be a determinant of disease development and/or progression and manipulation of miRNA expression represents a potential avenue of therapy. Exosomes are cell-derived extracellular vesicles that promote cell–cell communication and immunoregulatory functions. These “bioactive vesicles” shuttle various molecules, including miRNAs, to recipient cells. Inappropriate release of miRNAs from exosomes may cause significant alterations in biological pathways that affect disease development, supporting the concept that miRNA-containing exosomes could serve as targeted therapies for particular diseases. This review briefly summarizes recent advances in the biology, function, and therapeutic potential of exosomal miRNAs.Keywords
This publication has 106 references indexed in Scilit:
- Delivery of siRNA to the mouse brain by systemic injection of targeted exosomesNature Biotechnology, 2011
- Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/MacrophagesMolecular Therapy, 2011
- Inhibition of Myelin Membrane Sheath Formation by Oligodendrocyte-derived Exosome-like VesiclesPublished by Elsevier BV ,2011
- The role of REST in transcriptional and epigenetic dysregulation in Huntington's diseaseNeurobiology of Disease, 2010
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- Exosomes Released from Infected Macrophages Contain Mycobacterium avium Glycopeptidolipids and Are ProinflammatoryPublished by Elsevier BV ,2007
- Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosisBlood Cells, Molecules, and Diseases, 2005
- Identification of hundreds of conserved and nonconserved human microRNAsNature Genetics, 2005
- MicroRNAs: Genomics, Biogenesis, Mechanism, and FunctionCell, 2004
- Fas ligand mediates activation-induced cell death in human T lymphocytes.The Journal of Experimental Medicine, 1995