Cell Death
- 15 October 2009
- journal article
- review article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 361 (16), 1570-1583
- https://doi.org/10.1056/nejmra0901217
Abstract
This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy.Keywords
This publication has 132 references indexed in Scilit:
- Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009Cell Death & Differentiation, 2008
- Spatial differences in active caspase-8 defines its role in T-cell activation versus cell deathCell Death & Differentiation, 2008
- p53: The Janus of autophagy?Nature, 2008
- How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?Trends in Cell Biology, 2008
- Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of AutoimmunityImmunity, 2008
- Smac Mimetics and TNFα: A Dangerous Liaison?Cell, 2007
- Bcl-2-regulated apoptosis: mechanism and therapeutic potentialCurrent Opinion in Immunology, 2007
- An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal InjuryCell, 2007
- Adoptive transfer of dying cells causes bystander-induced apoptosisBiochemical and Biophysical Research Communications, 2007
- Cell Death: Critical Control PointsCell, 2004