Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives
Top Cited Papers
- 24 November 2020
- journal article
- review article
- Published by S. Karger AG in Dermatology
- Vol. 237 (1), 1-12
- https://doi.org/10.1159/000512932
Abstract
Background: Coronavirus disease-19 (COVID-19) is an ongoing global pandemic caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), which was isolated for the first time in Wuhan (China) in December 2019. Common symptoms include fever, cough, fatigue, dyspnea and hypogeusia/hyposmia. Among extrapulmonary signs associated with COVID-19, dermatological manifestations have been increasingly reported in the last few months. Summary: The polymorphic nature of COVID-19-associated cutaneous manifestations led our group to propose a classification, which distinguishes the following six main clinical patterns: (i) urticarial rash, (ii) confluent erythematous/maculopapular/morbilliform rash, (iii) papulovesicular exanthem, (iv) chilblain-like acral pattern, (v) livedo reticularis/racemosa-like pattern, (vi) purpuric “vasculitic” pattern. This review summarizes the current knowledge on COVID-19-associated cutaneous manifestations, focusing on clinical features and therapeutic management of each category and attempting to give an overview of the hypothesized pathophysiological mechanisms of these conditions.Keywords
This publication has 94 references indexed in Scilit:
- Reply to “COVID-19 can present with a rash and be mistaken for dengue”: Petechial rash in a patient with COVID-19 infectionJournal of the American Academy of Dermatology, 2020
- A dermatologic manifestation of COVID-19: Transient livedo reticularisJournal of the American Academy of Dermatology, 2020
- Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five casesTranslational Research, 2020
- Cutaneous manifestations in COVID‐19: a first perspectiveJournal of the European Academy of Dermatology and Venereology, 2020
- COVID-19 can present with a rash and be mistaken for dengueJournal of the American Academy of Dermatology, 2020
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaThe Lancet, 2020
- Overly Exuberant Innate Immune Response to SARS-CoV-2 InfectionSSRN Electronic Journal, 2020
- Impact of mycoplasma pneumonia infection on urticaria: A nationwide, population-based retrospective cohort study in TaiwanPLOS ONE, 2019
- Rook's Textbook of Dermatology, Ninth EditionPublished by Wiley ,2016
- Association between urticaria and virus infections: A systematic reviewAllergy and Asthma Proceedings, 2016