Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes
Open Access
- 1 January 2008
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 57 (1), 229-234
- https://doi.org/10.2337/db07-0289
Abstract
OBJECTIVE— The minor allele of the nonsynonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene is positively associated with type 1 diabetes and other autoimmune diseases. Genetic and functional data underline its causal effect, but some studies suggest that this polymorphism does not entirely explain disease association of the PTPN22 region. The aim of this study was to evaluate type 1 diabetes association within this gene in the Sardinian population.Keywords
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