Parental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult women
- 1 June 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Psychiatric Genetics
- Vol. 19 (3), 126-133
- https://doi.org/10.1097/ypg.0b013e32832a50a7
Abstract
Objectives Adverse childhood experiences are associated with poor mental health outcomes, including vulnerability to mood disorders and/or antisocial behavior. A functional polymorphism in the regulatory region of the monoamine oxidase A gene (monoamine oxidase A untranslated variable nucleotide tandem repeat, MAOA-uVNTR) may moderate the degree of risk conferred by early trauma. Experiential factors may mitigate or exacerbate the effects of trauma on individuals at genetic risk. We examined the association among MAOA-uVNTR genotype, early stress (family death, family separation, parents' divorce, physical and/or sexual abuse), quality of parental care, and disadvantageous outcomes (trait impulsivity/aggression and depression severity) in adult women. Methods Diagnostic assessments were completed for 159 female participants. All were either healthy or were diagnosed with major depressive disorder or bipolar disorder. Participants were assessed for lifetime trait aggression and impulsiveness and current severity of depression, and were genotyped for the MAOA-uVNTR polymorphism. Participants rated the level of parental care they experienced, and were asked to report specific childhood stressors and abuse. Results High perceived parental care mitigated the effect of a childhood stressor on impulsivity scores in low-expressing MAOA-uVNTR allele carriers, but level of perceived care had no effect in the group homozygous for the high-expressing MAOA-uVNTR allele. Gene–environment interactions did not influence depression severity in the mood disorder group, indicating that the effects of parenting we observed in our participants were independent of depression status. Conclusion These results suggest that gene–environment interactions influence not only disadvantageous outcomes, but also sensitivity to features of the environment that could alleviate these outcomes.Keywords
This publication has 43 references indexed in Scilit:
- Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgroundsDevelopment and Psychopathology, 2007
- Early Trauma and Increased Risk for Physical Aggression during Adulthood: The Moderating Role of MAOA GenotypePLOS ONE, 2007
- Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOAMolecular Psychiatry, 2007
- The monoamine oxidase A (MAO‐A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumptionAddiction, 2007
- Gene–environment correlations: a review of the evidence and implications for prevention of mental illnessMolecular Psychiatry, 2007
- Factorial Structure of the Parental Bonding Instrument (PBI) in Japan: A Study of Cultural, Developmental, and Gender InfluencesChild Psychiatry and Human Development, 2006
- MAOA, maltreatment, and gene–environment interaction predicting children's mental health: new evidence and a meta-analysisMolecular Psychiatry, 2006
- Neural mechanisms of genetic risk for impulsivity and violence in humansProceedings of the National Academy of Sciences of the United States of America, 2006
- Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatmentNeuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG), 2005
- Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatientsJournal of Neural Transmission, 2005