Factors Affecting Gastrointestinal Microbiome Development in Neonates
Open Access
- 28 February 2018
- Vol. 10 (3), 274
- https://doi.org/10.3390/nu10030274
Abstract
The gut microbiome is established in the newborn period and is recognised to interact with the host to influence metabolism. Different environmental factors that are encountered during this critical period may influence the gut microbial composition, potentially impacting upon later disease risk, such as asthma, metabolic disorder, and inflammatory bowel disease. The sterility dogma of the foetus in utero is challenged by studies that identified bacteria, bacterial DNA, or bacterial products in meconium, amniotic fluid, and the placenta; indicating the initiation of maternal-to-offspring microbial colonisation in utero. This narrative review aims to provide a better understanding of factors that affect the development of the gastrointestinal (GI) microbiome during prenatal, perinatal to postnatal life, and their reciprocal relationship with GI tract development in neonates.Keywords
This publication has 120 references indexed in Scilit:
- The intestinal microbiota dysbiosis andClostridium difficileinfection: is there a relationship with inflammatory bowel disease?Therapeutic Advances in Gastroenterology, 2012
- Human gut microbiome viewed across age and geographyNature, 2012
- Ability of Bifidobacterium breve To Grow on Different Types of Milk: Exploring the Metabolism of Milk through Genome AnalysisApplied and Environmental Microbiology, 2011
- Antibiotic use and inflammatory bowel diseases in childhoodGut, 2010
- Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newbornsProceedings of the National Academy of Sciences of the United States of America, 2010
- 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitisThe ISME Journal, 2009
- The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiomeProceedings of the National Academy of Sciences of the United States of America, 2008
- Bacteria in the Intestine, Helpful Residents or Enemies from Within?Infection and Immunity, 2008
- Transcriptome profiling of the small intestinal epithelium in germfree versus conventional pigletsBMC Genomics, 2007
- Optimum oxygen therapy in preterm babiesArchives of Disease in Childhood: Fetal & Neonatal, 2007