Ascorbate Autoxidation in the Presence of Iron and Copper Chelates
- 1 January 1986
- journal article
- research article
- Published by Informa UK Limited in Free Radical Research Communications
- Vol. 1 (6), 349-353
- https://doi.org/10.3109/10715768609051638
Abstract
Chelates can inhibit the iron- and copper-catalyzed autoxidation of ascorbate at pH 7.0. Diethylenetri-aminepentaacetic acid (DTPA or DETAPAC) and Desferal (deferoximane mesylate) slow the iron-catalyzed oxidation of ascorbate as effectively as reducing the trace levels of contaminating iron in buffers with Chelex resin. DETAPAC, EDTA and HEDTA (N-(2-hydroxyethyl)-ethylenediaminetriacetic acid) are effective at slowing the copper-catalyzed autoxidation of ascorbate while Desferal is ineffective. The ability to inhibit ascorbate autoxidation appears to parallel the rate of the reaction of superoxide with the iron chelate.Keywords
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