Raman Assessment of Bone Quality
Top Cited Papers
Open Access
- 1 August 2011
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Orthopaedics and Related Research
- Vol. 469 (8), 2160-2169
- https://doi.org/10.1007/s11999-010-1692-y
Abstract
Progress in the diagnosis and prediction of fragility fractures depends on improvements to the understating of the compositional contributors of bone quality to mechanical competence. Raman spectroscopy has been used to evaluate alterations to bone composition associated with aging, disease, or injury. In this survey we will (1) review the use of Raman-based compositional measures of bone quality, including mineral-to-matrix ratio, carbonate-to-phosphate ratio, collagen quality, and crystallinity; (2) review literature correlating Raman spectra with biomechanical and other physiochemical measurements and with bone health; and (3) discuss prospects for ex vivo and in vivo human subject measurements. ISI Web of Science was searched for references to bone Raman spectroscopy in peer-reviewed journals. Papers from other topics have been excluded from this review, including those on pharmaceutical topics, dental tissue, tissue engineering, stem cells, and implant integration. Raman spectra have been reported for human and animal bone as a function of age, biomechanical status, pathology, and other quality parameters. Current literature supports the use of mineral-to-matrix ratio, carbonate-to-phosphate ratio, and mineral crystallinity as measures of bone quality. Discrepancies between reports arise from the use of band intensity ratios rather than true composition ratios, primarily as a result of differing collagen band selections. Raman spectroscopy shows promise for evaluating the compositional contributors of bone quality in ex vivo specimens, although further validation is still needed. Methodology for noninvasive in vivo assessments is still under development.Keywords
This publication has 82 references indexed in Scilit:
- Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneityBone, 2010
- Quantitative polarized Raman spectroscopy in highly turbid bone tissueJournal of Biomedical Optics, 2010
- Inbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient MiceAnnals of Biomedical Engineering, 2009
- Functional Grading of Mineral and Collagen in the Attachment of Tendon to BoneBiophysical Journal, 2009
- Prior treatment with vitamin K2 significantly improves the efficacy of risedronateOsteoporosis International, 2009
- Stress mapping of undamaged, strained, and failed regions of bone using Raman spectroscopyJournal of Biomedical Optics, 2009
- The Tendon-to-Bone Transition of the Rotator Cuff: A Preliminary Raman Spectroscopic Study Documenting the Gradual Mineralization across the Insertion in Rat Tissue SamplesApplied Spectroscopy, 2008
- Exercise Alters Mineral and Matrix Composition in the Absence of Adding New BoneCells Tissues Organs, 2008
- Noninvasive Raman tomographic imaging of canine bone tissueJournal of Biomedical Optics, 2008
- Skeletal Self-Repair : Stress Fracture Healing by Rapid Formation and Densification of Woven BoneJournal of Bone and Mineral Research, 2007