Toll-Like Receptor Signaling Pathways
Top Cited Papers
Open Access
- 25 September 2014
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 5, 461
- https://doi.org/10.3389/fimmu.2014.00461
Abstract
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the transcription factors NF-κB and IRFs, which dictate the outcome of innate immune responses. During the past decade, the precise mechanisms underlying TLR signaling have been clarified by various approaches involving genetic, biochemical, structural, cell biological and bioinformatics studies. TLR signaling appears to be divergent and to play important roles in many aspects of the innate immune responses to given pathogens. In this review, we describe recent progress in our understanding of TLR signaling regulation and its contributions to host defense.Keywords
This publication has 84 references indexed in Scilit:
- The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and SignalingMolecular Cell, 2014
- Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infectionProceedings of the National Academy of Sciences of the United States of America, 2014
- Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and MacrophagesThe Journal of Immunology, 2013
- TLR7 and TLR9 in SLE: when sensing self goes wrongImmunologic Research, 2012
- The Structural Biology of Toll-like ReceptorsStructure, 2011
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsNature Immunology, 2010
- Intracellular Toll-like ReceptorsImmunity, 2010
- TLR3 Deficiency in Patients with Herpes Simplex EncephalitisScience, 2007
- Pathogen Recognition and Innate ImmunityCell, 2006
- Innate Immune RecognitionAnnual Review of Immunology, 2002