Antidepressant efficacy and immune effects of bilateral theta burst stimulation monotherapy in major depression: A randomized, double-blind, sham-controlled study

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Abstract
This is the first study investigating the antidepressant efficacy of bilateral theta-burst stimulation (TBS) monotherapy. Bilateral TBS monotherapy is effective for the treatment of major depression. This is the first study investigating the effects of TBS on a broad array of inflammatory cytokines including interleukin (IL) -1β, IL-12p40, IL-2, IL-4, IL-5, IL-6, IFN-γ inducible protein 10 and C-reactive protein.
Funding Information
  • Ministry of Science and Technology, Taiwan (106-2314-B-039-027-MY3, 108-2314-B-039-016, 108-2320-B-039-048, 108-2813-C-039-133-B, NHRI-EX108-10528NI)
  • Universidade de Macau (CMRC-CMA-3)
  • National Health Research Institutes (MYRG2018-00242-ICMS)
  • China Medical University, Taiwan (CRS-108-048, DMR-108-216, DMR-109-102, DMR-109-244, DMR-HCC-109-12, DMR-HHC-109-11)
  • Ministry of Education (CMU108-SR-106)
  • China Medical University Hospital