The Amino‐Acid Sequence of S‐100 Protein (PAP I‐b Protein) and Its Relation to the Calcium‐Binding Proteins

Abstract
The amino acid sequence of a brain‐specific protein, S‐100, has been determined by the analysis of four cyanogen bromide peptides and fourteen tryptic peptides derived from the protein. The protein chain consists of 91 amino acid residues and has a molecular weight of 10 507. The sequence shows regions of strong clustering of hydrophobic, basic and acidic amino acids, with an apparent calcium‐binding site in the acidic cluster.