5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase
- 21 October 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 46 (24), 5249-5257
- https://doi.org/10.1021/jm030327l
Abstract
The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel nonnucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogues that are potent inhibitors of adenosine kinase with in vivo analgesic activity.Keywords
This publication has 8 references indexed in Scilit:
- Pyridopyrimidine analogues as novel adenosine kinase inhibitorsBioorganic & Medicinal Chemistry Letters, 2001
- Discovery of 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine, an Orally Active, Non-Nucleoside Adenosine Kinase InhibitorJournal of Medicinal Chemistry, 2001
- Characterization of the Effects of Adenosine Kinase Inhibitors on Acute Thermal Nociception in MicePharmacology Biochemistry and Behavior, 1999
- Quantitation of T-cell receptor V? chain expression on lymphocytes from blood, brain, and spinal fluid in patients with multiple sclerosis and other neurological diseasesAnnals of Neurology, 1992
- Endogenous anticonvulsant substancesNeuroscience & Biobehavioral Reviews, 1986
- Adenosine and the concept of ‘retaliatory metabolites’Trends in Biochemical Sciences, 1984
- N-methoxy-n-methylamides as effective acylating agentsTetrahedron Letters, 1981
- The Reaction of diazomethane with double bonds.- Part III. A stepwise and improved buchner-curtius-schlotterbeck reactionTetrahedron Letters, 1963