Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women
Open Access
- 1 January 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 26 (1), 189-193
- https://doi.org/10.1161/01.atv.0000191656.71812.7c
Abstract
Objective— Although the metabolic syndrome (MS) is associated with increased cardiovascular risk, its relationship with atherosclerotic progression is less well defined. We sought to determine whether the MS predicts angiographic progression of coronary heart disease in a cohort of postmenopausal women. Methods and Results— A total of 309 postmenopausal women entered the Estrogen Replacement and Atherosclerosis trial, of whom 248 underwent baseline angiography and completed follow-up angiography after an average of 3.2 years. Women were identified as having type 2 diabetes mellitus (T2DM) or the MS (National Cholesterol Education Panel diagnostic criteria). In adjusted models, participants with T2DM and the MS had greater angiographic progression [change in minimal diameter (ΔMD): −0.15] than women without T2DM or the MS (ΔMD: −0.08; P P P =0.54)]. In adjusted logistic regression models, T2DM predicted coronary heart disease events [odds ratio, 2.79 (95% CI, 1.29 to 6.02)], and the MS demonstrated a similar trend [odds ratio, 1.98 (95% CI, 0.90 to 4.33)]. Conclusions— Among postmenopausal women with coronary heart disease, the presence of diabetes predicted disease progression, but the MS did not.Keywords
This publication has 35 references indexed in Scilit:
- C-Reactive Protein, the Metabolic Syndrome, and Prediction of Cardiovascular Events in the Framingham Offspring StudyCirculation, 2004
- Prevalence of the Metabolic Syndrome and Its Relation to All-Cause and Cardiovascular Mortality in Nondiabetic European Men and WomenArchives of Internal Medicine, 2004
- Metabolic Syndrome With and Without C-Reactive Protein as a Predictor of Coronary Heart Disease and Diabetes in the West of Scotland Coronary Prevention StudyCirculation, 2003
- Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final ReportCirculation, 2002
- The Metabolic Syndrome and Total and Cardiovascular Disease Mortality in Middle-aged MenJAMA, 2002
- Explaining the Sex Difference in Coronary Heart Disease Mortality Among Patients With Type 2 Diabetes MellitusArchives of Internal Medicine, 2002
- Cardiovascular Morbidity and Mortality Associated With the Metabolic SyndromeDiabetes Care, 2001
- The Estrogen Replacement and Atherosclerosis (ERA) Study: Study Design and Baseline Characteristics of the CohortControlled Clinical Trials, 2000
- Insulin Resistance Syndrome Predicts Coronary Heart Disease Events in Elderly Nondiabetic MenCirculation, 1999
- Role of Insulin Resistance in Human DiseaseDiabetes, 1988