Topical Antiinflammatory Activity of Essential Oil of Lippia sidoides Cham: Possible Mechanism of Action
- 18 April 2012
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 27 (2), 179-185
- https://doi.org/10.1002/ptr.4695
Abstract
This work reports the chemical composition of the essential oil of Lippia sidoides (EOLS) and evaluation of the topical effect of EOLS and thymol against different irritant agents in vivo. The essential oil was obtained by hydrodistillation, and gas chromatography/mass spectrometry analysis identified the main constituents: thymol (84.9%) and p-cymene (5.33%). The antiinflammatory activity was evaluated using the mouse models of acute ear inflammation induced by croton oil, arachidonic acid, phenol or histamine, and chronic inflammation induced by croton oil. The topical application of EOLS or thymol at a dose of 2 mg/ear significantly reduced (p < 0.001) ear edema induced with arachidonic acid by 45.1% and 47.4% and reduced ear edema induced with phenol by 33.2% (p < 0.05) and 54.7% (p < 0.01) in acute ear edema. However, a proinflammatory effect of EOLS and thymol was evidenced when it was applied for more than 1 day. There were no statistical differences in antiedematogenic activity between EOLS and thymol. In conclusion, the results indicate that thymol is the constituent responsible for the topical antiinflammatory activity of EOLS. Thus, these findings could justify the popular use of L. sidoides by alternative medicine, but chronic use has an inflammatory effect. Copyright © 2012 John Wiley & Sons, Ltd.This publication has 29 references indexed in Scilit:
- Anti-inflammatory effects of compounds alpha-humulene and (−)-trans-caryophyllene isolated from the essential oil of Cordia verbenaceaEuropean Journal of Pharmacology, 2007
- Chemical composition, toxicological aspects and antifungal activity of essential oil from Lippia sidoides Cham.Journal of Antimicrobial Chemotherapy, 2007
- Preliminary study on immunological and behavioural effects of Thymus broussonetii Boiss., an endemic species in MoroccoJournal of Ethnopharmacology, 2006
- Review of the plants with anti-inflammatory activity studied in BrazilRevista Brasileira de Farmacognosia, 2005
- Chemical composition and antimicrobial activity of the essential oil of Cordiaverbenacea D.C.Journal of Ethnopharmacology, 2004
- Tea tree oil reduces histamine-induced oedema in murine earsInflammation Research, 2002
- Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L.Biological & Pharmaceutical Bulletin, 2001
- Inhibition of arachidonic acid-induced ear oedema as a model for assessing topical anti-inflammatory compoundsInflammation Research, 1987
- Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agentsInflammation Research, 1985
- Prostaglandins, hydroxy fatty acids, leukotrienes and inflammation of the skinClinical and Experimental Dermatology, 1982