Vagus Nerve Stimulation in Humans: Neurophysiological Studies and Electrophysiological Monitoring
- 1 June 1990
- Vol. 31 (s2), S51-S59
- https://doi.org/10.1111/j.1528-1157.1990.tb05850.x
Abstract
Evidence from studies of experimental animals indicates that electrical stimulation of the vagus nerve alters behavioral and electrographic seizure activity. We report on effects of electrical stimulation of the vagus nerve in five patients with medically intractable seizures as part of a clinical trial of chronic vagal stimulation for control of epilepsy. The mechanism of action of the vagal antiepileptic effect is unknown, and it is hoped that analysis of electrophysiological effects of vagal nerve stimulation will help elucidate which brain areas are affected. Stimulation of the left vagus nerve in the neck was accomplished with a programmable implanted stimulator. Effects of stimulus amplitude, duration, and rate were studied. Noncephalic reference recording of the vagus-nerve-evoked potential showed some unusual properties: a scalp negative component occurred with latency of 12 ms, very high amplitude (up to 60 microV), and widespread scalp distribution. Field distribution studies indicate that this potential is generated in the neck, in the region of the stimulating electrodes. Muscle paralysis confirms this observation. Stimulation at various frequencies had no noticeable effect on electroencephalographic (EEG) activity regardless of whether the patient was under general anesthesia, awake, or asleep.Keywords
This publication has 12 references indexed in Scilit:
- Effects of Vagal Stimulation on Experimentally Induced Seizures in RatsEpilepsia, 1990
- Vagal afferent inhibition of primate thoracic spinothalamic neuronsJournal of Neurophysiology, 1983
- Descending inhibition of spinal neurons in the cardiopulmonary region by electrical stimulation of vagal afferent nervesBrain Research, 1981
- Vagal representation in the cerebellum of the catPflügers Archiv - European Journal of Physiology, 1978
- A pontine primary relay for ascending projections of the superior laryngeal nerveExperimental Brain Research, 1975
- Evoked cortical responses to vagal, laryngeal and facial afferents in monkeys under chloralose anaesthesiaElectroencephalography and Clinical Neurophysiology, 1971
- Electrical Responses of the Hippocampus to Stimulation of the Vagus NervePublished by Springer Science and Business Media LLC ,1970
- Afferent vagal stimulation: Neurographic correlates of induced eeg synchronization and desynchronizationBrain Research, 1967
- A SENSORY CORTICAL REPRESENTATION OF THE VAGUS NERVE: WITH A NOTE ON THE EFFECTS OF LOW BLOOD PRESSURE ON THE CORTICAL ELECTROGRAMJournal of Neurophysiology, 1938
- Effects on the knee jerk of stimulation of the central end of the vagus and of various changes in the circulation and respirationThe Journal of Physiology, 1937