RIBAVIRIN SUPPRESSES REPLICATION OF LYMPHADENOPATHY-ASSOCIATED VIRUS IN CULTURES OF HUMAN ADULT T LYMPHOCYTES

Abstract
The in-vitro effect of ribavirin on the replication of lymphadenopathy-associated virus (LAV), one of the prototype viruses aetiologically associated with lymphadenopathy syndrome and acquired immunodeficiency syndrome, was tested. Ribavirin, a nucleoside, suppressed the replication of LAV in cultures of human adult T lymphocytes. Suppression occurred at ribavirin concentrations of 50 μg/ml or higher.