Global Metabolite Profiling Reveals Transformation Pathways and Novel Metabolomic Responses in Solea senegalensis after Exposure to a Non-ionic Surfactant
- 31 March 2014
- journal article
- research article
- Published by American Chemical Society (ACS) in Environmental Science & Technology
- Vol. 48 (9), 5203-5210
- https://doi.org/10.1021/es501276g
Abstract
Alcohol polyethoxylate (AEO) surfactants are widely used in household and industrial products, but the health effects arising from short-term exposure to sublethal concentrations are unknown. A metabolomic approach was used to investigate the biotransformation and effects of exposure to sublethal concentrations of hexaethylene glycol monododecylether (C12EO6) in juvenile sole, Solea senegalensis. After 5 days, C12EO6 was rapidly metabolized in the sole by oxidation, glucuronidation, and ethoxylate chain shortening. C12EO6 exposure at either 146 or 553 μg L–1 resulted in significant metabolite disruption in liver and blood samples, including an apparent fold increase of >106 in the circulating levels of C24 bile acids and C27 bile alcohols, disturbance of glucocorticoid and lipid metabolism, and a 470-fold decrease in levels of the fatty acid transport molecule palmitoyl carnitine. Depuration resulted in rapid elimination of the surfactant and normalization of metabolites toward pre-exposure levels. Our findings show for the first time the ability of metabolomic analyses to discern effects of this AEO on metabolite homeostasis at exposure levels below its no effect concentrations for survival and reproduction in juvenile fish. The pronounced alteration in levels of liver metabolites, phospholipids, and glucocorticoids in S. senegalensis in response to surfactant exposure may indicate that this contaminant could potentially impact a number of health end points in fish.Keywords
This publication has 42 references indexed in Scilit:
- Nuclear receptors in bile acid metabolismDrug Metabolism Reviews, 2013
- Toxicity Ranking and Toxic Mode of Action Evaluation of Commonly Used Agricultural Adjuvants on the Basis of Bacterial Gene Expression ProfilesPLOS ONE, 2011
- Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in miceHepatology, 2011
- Ultra Performance Liquid Chromatography-Mass Spectrometry Profiling of Bile Acid Metabolites in Biofluids: Application to Experimental Toxicology StudiesAnalytical Chemistry, 2010
- Influence of the molecular structure and exposure concentration on the uptake and elimination kinetics, bioconcentration, and biotransformation of anionic and nonionic surfactantsEnvironmental Toxicology and Chemistry, 2010
- Bile salts of vertebrates: structural variation and possible evolutionary significanceJournal of Lipid Research, 2010
- 'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellusBMC Biology, 2008
- Lipid peroxidation: Mechanisms, inhibition, and biological effectsBiochemical and Biophysical Research Communications, 2005
- OCCURRENCE AND DISTRIBUTION OF NONIONIC SURFACTANTS, THEIR DEGRADATION PRODUCTS, AND LINEAR ALKYLBENZENE SULFONATES IN COASTAL WATERS AND SEDIMENTS IN SPAINEnvironmental Toxicology and Chemistry, 2002
- Membrane toxicity of linear alcohol ethoxylatesEnvironmental Toxicology and Chemistry, 1999