Neuroimaging and Correlates of Cognitive Function among Patients with Heart Failure
- 15 October 2007
- journal article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 24 (6), 418-423
- https://doi.org/10.1159/000109811
Abstract
We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF). In 58 patients with HF neuropsychological assessment was performed including tests of mental speed, executive functions, memory, language and visuospatial functions. Deep, periventricular and total white matter hyperintensities (WMH), lacunar and cortical infarcts, global and medial temporal lobe atrophy (MTA) were investigated on MRI of the brain. Correlations between MRI findings and the cognitive measures were calculated. MTA correlated with memory (r = -0.353, p < 0.01), with executive functions (r = -0.383, p < 0.01) and the Mini Mental State Examination (r = -0.343, p < 0.05). Total WMH and deep WMH were found to correlate with depression and anxiety scores, but not with cognitive measures. Age, estimated premorbid intelligence and MTA were independent predictors of diminished cognitive performance. In HF patients, MTA was related to cognitive dysfunction, involving memory impairment and executive dysfunction, whereas WMH was related to depression and anxiety.This publication has 33 references indexed in Scilit:
- Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS studyJournal of Neurology, Neurosurgery & Psychiatry, 2005
- Cardiovascular risk factors and Alzheimer’s diseaseCurrent Atherosclerosis Reports, 2004
- Regional brain gray matter loss in heart failureJournal of Applied Physiology, 2003
- Heart FailureThe New England Journal of Medicine, 2003
- Periventricular cerebral white matter lesions predict rate of cognitive declineAnnals of Neurology, 2002
- Hypertension and cerebral white matter lesions in a prospective cohort studyBrain, 2002
- Cambridge Neuropsychological Test Automated Battery (CANTAB): A Factor Analytic Study of a Large Sample of Normal Elderly VolunteersDementia and Geriatric Cognitive Disorders, 1994
- A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imagingJournal of the Neurological Sciences, 1993
- Brain magnetic resonance imaging and neuropsychologic evaluation of patients with idiopathic dilated cardiomyopathy.Stroke, 1991
- Effect of Age on Performance of the Trail Making TestPerceptual and Motor Skills, 1973