An Outbreak of a New Infectious Disease COVID-19: β-coronaviruses as a Threat to Global Healthcare
- 25 March 2020
- journal article
- Published by SCEEMP in Biological Products. Prevention, Diagnosis, Treatment
Abstract
Coronaviruses are the largest group of known positive-strand RNA viruses. Coronavirus infection can affect various animal species, as well as humans. Over the past two decades, coronaviruses have caused epidemic outbreaks of two respiratory diseases: the Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. At the end of 2019, a new type of virus was detected in China. The virus has been spread by humantohuman transmission and has caused a viral pneumonia outbreak. The emergence of a new coronavirus proves that the diseases caused by this group of viruses pose a threat to global health due to the potential for a pandemic, and, therefore, need careful monitoring. The objective of the study was to analyse the current epidemic situation for the new coronavirus infection (COVID-19) caused by SARS-CoV-2, taking into account previous outbreaks of infections caused by MERS-CoV and SARS-CoV β-coronaviruses which pose the greatest threat to human health. The review briefly describes two epidemic outbreaks caused by SARS-CoV (2002–2004) and MERS-CoV (2012–present), summarises the current epidemic situation for the new SARS-CoV-2 coronavirus, describes the main restrictive measures undertaken to prevent the spread of infection in Russia. The paper considers aspects of potential specific therapy and the development of prophylactic vaccines against the new coronavirus infection. The review concludes that SARS-CoV-2 has pandemic potential and that new strains of β-coronaviruses are likely to cause outbreaks in the future. The paper points to the need for careful monitoring of the disease and conducting preventive anti-epidemic measures to curb the spread of infection.Keywords
This publication has 51 references indexed in Scilit:
- Economic impacts of Wuhan 2019‐nCoV on China and the worldJournal of Medical Virology, 2020
- Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study GroupPublished by Cold Spring Harbor Laboratory ,2020
- Coronavirus infections and immune responsesJournal of Medical Virology, 2020
- Emerging coronaviruses: Genome structure, replication, and pathogenesisJournal of Medical Virology, 2020
- From SARS to MERS, Thrusting Coronaviruses into the SpotlightViruses, 2019
- Origin and evolution of pathogenic coronavirusesNature Reviews Microbiology, 2018
- MERS-CoV spike protein: a key target for antiviralsEmerging Therapeutic Targets, 2016
- Molecular mechanisms of coronavirus RNA capping and methylationVirologica Sinica, 2016
- Emerging Coronavirus Which Gives Rise to the Disease in HumansProblems of Particularly Dangerous Infections, 2015
- Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and DeltacoronavirusJournal of Virology, 2012