Nutritional Composition, Antioxidant Activities, and Antiulcer Potential ofLentinus squarrosulus(Mont.) Mycelia Extract

Abstract

Water extract ofLentinus squarrosulusmycelia was analysed for nutritional content, antioxidant capacity, and antiulcer ability. The extract contains high protein (57.6 g/100 g) and low total fat (0.5 g/100 g) and is rich in magnesium (0.4 g/100 g), potassium (3.8 g/100 g), vitamins B₁(1.42 mg/100 g), and B₃(194.29 mg/100 g) with total phenolic content of 39.16 mg/100 g. The cupric reducing antioxidant capacity and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of the extract were A₄₅₀of 0.20 ± 0.03 at 0.5 mg/ml and IC₅₀of 14.29 mg/ml, respectively. Oral feeding ofL. squarrosulusextract (250 mg/kg) offered significant gastric mucosal protection of Sprague-Dawley rats compared to cimetidine (50 mg/kg). The ulcer healing rate of ulcerated rats after 24, 48, and 72 hours of treatment was 82%, 90%, and 100%, respectively. The IL-1β level in the serum and the NF-κB level in the tissues indicate that the healing potential was associated with attenuation of proinflammatory cytokines.