Imaging‐guided and nonimaging‐guided fine needle aspiration of liver lesions: Experience with 406 patients
- 1 December 1991
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 48 (4), 246-251
- https://doi.org/10.1002/jso.2930480407
Abstract
The aim of the present study was to determine the diagnostic accuracy of different modes of fine needle aspiration (FNA) of liver lesions. A total of 492 FNAs wereperformed on 406 patients in order to confirm or to rule out focal or multifocal neoplastic disease: 29% under ultrasound (US) guidance, 3% with computed tomographic (CT) guidance, 67% preoperatively, and 1% intraoperatively without imaging guidance. Based on histologic, cytologic, and clinical findings, final diagnoses were reached in 387 patients, of whom 264 had malignant liver disease and 123 had benign liver disease. Of 321 aspirations performed in patients with malignant liver disease, the cytologic findings suggested malignancy in 225 (70.1%) suspected malignancy in 25 (7.8%), and did not reveal malignancy in 71 aspirations (22.1%). Among the 123 patients with benign liver disease, the cytologic findings were reported as benign in all but two patients, who had false-positive cytologic findings. The overall sensitivity, specificity, positive, and negative predictive values for cytologic findings were 85.6, 98.4, 99.1, and 76.1%, respectively. The overall diagnostic accuracy was 89.7%. In one patient, fatal intraperitoneal bleeding due to chronic intravascular coagulation complicated the FNA procedure. We conclude that imaging-guided FNA as well as nonguided FNA for cytologic diagnosis of liver lesions are highly accurate and only rarely may be associated with a fatal complication.Keywords
This publication has 24 references indexed in Scilit:
- The Value of Chiba Fine-Needle Aspiration Biopsy in the Diagnosis of Hepatic MalignancyJournal of Clinical Gastroenterology, 1989
- Clinical and Diagnostic Features of 67 Cases of Hepatocellular CarcinomaOncology, 1987
- Percutaneous Fine Needle BiopsyClinics in Gastroenterology, 1985
- Value of heparinized fine-needle aspiration biopsy in liver malignancyAmerican Journal of Roentgenology, 1985
- Cytohistologic diagnosis of neoplasms of the liver by ultrasonically guided fine-needle aspiration biopsyCancer, 1984
- Cytologic diagnosis of hepatocellular carcinoma by fine-needle aspiration biopsyCancer, 1984
- Ultrasonically guided fine-needle biopsies in neoplastic liver disease: Cytohistologic diagnoses and echo pattern of lesionsCancer, 1981
- Guided percutaneous fine-needle aspiration biopsy of the liverCancer, 1981
- Carcinoma of the Liver: Cytopathologic DiagnosisJournal of the American Geriatrics Society, 1978
- Fine needle aspiration biopsy of malignant lesions in and around the pancreasCancer, 1978