O-linked mucin-type glycosylation in breast cancer
Open Access
- 20 August 2018
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 46 (4), 779-788
- https://doi.org/10.1042/BST20170483
Abstract
Changes in mucin-type O-linked glycosylation are seen in over 90% of breast cancers where increased sialylation is often observed and a change from branched glycans to linear glycans is often seen. There are many mechanisms involved including increased/altered expression of glycosyltransferases and relocalisation to the endoplasmic reticulum of the enzymes responsible for the addition of the first sugar, N-acetyl-D-galactosamine. It is now becoming clear that these changes can contribute to tumour growth and progression by modulating the micro-environment through glycan-sensing lectins expressed on immune cells, by modulating interactions with tumour surface receptors and by binding to selectins. The understanding of how changes in mucin-type O-linked glycosylation influence tumour growth and progression reveals new potential targets for therapeutic intervention in the treatment of breast cancer.Keywords
This publication has 77 references indexed in Scilit:
- Targeting sialic acid–Siglec interactions to reverse immune suppression in cancerGlycobiology, 2017
- Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cellsCell Death & Differentiation, 2017
- Tumor–stroma crosstalkCurrent Opinion in Oncology, 2014
- Siglec-mediated regulation of immune cell function in diseaseNature Reviews Immunology, 2014
- An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis SuppressorCancer Discovery, 2014
- Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasionNature Chemical Biology, 2013
- Binding of the Sialic Acid-binding Lectin, Siglec-9, to the Membrane Mucin, MUC1, Induces Recruitment of β-Catenin and Subsequent Cell GrowthPublished by Elsevier BV ,2013
- Tn and sialyl‐Tn antigens, aberrant O‐glycomics as human disease markersProteomics – Clinical Applications, 2013
- A Transfected Sialyltransferase That Is Elevated in Breast Cancer and Localizes to the medial/trans-Golgi Apparatus Inhibits the Development of core-2–based O-GlycansThe Journal of cell biology, 1997
- Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines:Published by Elsevier BV ,1996