Association of Cerebrospinal Fluid Analysis Findings with Clinical Signs and Outcome in Acute Nonambulatory Thoracolumbar Disc Disease in Dogs
- 20 June 2011
- journal article
- research article
- Published by Wiley in Journal of Veterinary Internal Medicine
- Vol. 25 (4), 846-855
- https://doi.org/10.1111/j.1939-1676.2011.0739.x
Abstract
Background: Cerebrospinal fluid (CSF) pleocytosis recently was associated with the severity of neurologic signs in dogs with intervertebral disc disease (IVDD Hypothesis/Objectives: To look for an association among CSF cell counts, total protein concentration, and severity of neurologic signs at presentation with outcome in dogs with acute thoracolumbar IVDD. Our hypothesis was that CSF total nucleated cell count (TNCC) and percentage cell types would be associated with the severity of spinal cord damage and therefore with both the presenting clinical signs and the prognosis of affected dogs. Animals: Fifty-four dogs with acute nonambulatory thoracolumbar IVDD were evaluated. Methods: Retrospective study. Signalment, neurologic grade, CSF TNCC, protein concentration, red blood cells count and differential cell percentages, and short-and long-term outcomes were evaluated. Results: CSF pleocytosis (>5 cells/mu L) was present in 54% of dogs and was positively associated with neurologic grade at presentation and with postoperative time to regaining ambulation. Neutrophils were observed most frequently. The percentage of CSF macrophages and macrophage to monocyte ratio were higher (P = .001, for both) in dogs presented without deep pain sensation (DPS) that did not regain ambulation. Receiver operator characteristics curve analysis yielded a cut-off point of 13% macrophages with a sensitivity and specificity of 100 and 83%, respectively, for prediction of a negative outcome. Conclusions and Clinical Importance: CSF pleocytosis is positively associated with the severity of spinal cord damage in dogs with thoracolumbar IVDD. The percentage of CSF macrophages can be used as a prognostic indicator for regaining ambulation in dogs that have lost DPS.Keywords
This publication has 27 references indexed in Scilit:
- Cerebrospinal Fluid Myelin Basic Protein as a Prognostic Biomarker in Dogs with Thoracolumbar Intervertebral Disk HerniationJournal of Veterinary Internal Medicine, 2010
- Cerebrospinal Fluid Inflammatory Cytokines and Biomarkers of Injury Severity in Acute Human Spinal Cord InjuryJournal of Neurotrauma, 2010
- Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutaseExperimental Neurology, 2009
- Magnetic Resonance Imaging in Dogs with Neurologic Impairment Due to Acute Thoracic and Lumbar Intervertebral Disk HerniationJournal of Veterinary Internal Medicine, 2009
- Cytologic interpretation of canine cerebrospinal fluid samples with low total nucleated cell concentration, with and without blood contaminationVeterinary Clinical Pathology, 2009
- Lumbar Cerebrospinal Fluid in Dogs with Type I Intervertebral Disc HerniationJournal of Veterinary Internal Medicine, 2008
- Association of spinal cord compression seen on magnetic resonance imaging with clinical outcome in 67 dogs with thoracolumbar intervertebral disc extrusionJournal of Small Animal Practice, 2006
- Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk diseaseAmerican Journal of Veterinary Research, 2006
- Canine intervertebral disc disease: Changes in the cerebrospinal fluidJournal of Small Animal Practice, 1989
- Results of surgical treatment for thoracolumbar disc protrusion*Journal of Small Animal Practice, 1972