Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
Open Access
- 3 March 2006
- journal article
- patterns and-phenotypes
- Published by Wiley in Developmental Dynamics
- Vol. 235 (6), 1659-1667
- https://doi.org/10.1002/dvdy.20729
Abstract
Matricellular proteins mediate both tissue morphogenesis and tissue homeostasis in important ways because they modulate cell–matrix and cell–cell interactions. In this study, we found that the matricellular protein osteopontin (Opn) is a novel marker of undifferentiated pancreatic precursors and pancreatic ductal tissues in mice. Our analysis also underscored a specific, dynamic profile of Opn expression in embryonic pancreatic tissues that suggests the participation of this protein's function in processes involving cell migration, cell–cell interactions, or both. Surprisingly, our analysis of Opn‐deficient pancreata did not reveal obvious alterations in the morphology or differentiation of these tissues. Therefore, in embryonic pancreatic tissues, it is possible that other proteins act redundantly to Opn or that this protein's function is dispensable for pancreas development. Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses. Developmental Dynamics 235:1659–1667, 2006.Keywords
This publication has 31 references indexed in Scilit:
- Gli3 null mice display glandular overgrowth of the developing stomachDevelopmental Dynamics, 2005
- Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis developmentDevelopmental Dynamics, 2005
- Three small integrin‐binding ligand N‐linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinasesThe FASEB Journal, 2004
- The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiationDevelopmental Biology, 2004
- Osteopontin modulates CD44‐dependent chemotaxis of peritoneal macrophages through G‐protein‐coupled receptors: Evidence of a role for an intracellular form of osteopontinJournal of Cellular Physiology, 2003
- Alterations of Arterial Physiology in Osteopontin-Null MiceArteriosclerosis, Thrombosis, and Vascular Biology, 2003
- Pancreatic organogenesis — developmental mechanisms and implications for therapyNature Reviews Genetics, 2002
- Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survivalJCI Insight, 2001
- Flexible Structures of SIBLING Proteins, Bone Sialoprotein, and OsteopontinBiochemical and Biophysical Research Communications, 2001
- Altered wound healing in mice lacking a functional osteopontin gene (spp1).JCI Insight, 1998