Inflammation and metabolic disorders
- 1 July 2008
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Clinical Nutrition and Metabolic Care
- Vol. 11 (4), 459-464
- https://doi.org/10.1097/mco.0b013e32830460c2
Abstract
Poor nutrition, overweight and obesity have increasingly become a public health concern as they affect many metabolic disorders, including heart disease, diabetes, digestive system disorders, and renal failure. Study of the effects of life style including healthy nutrition will help further elucidate the mechanisms involved in the adverse effects of poor nutrition.Unhealthy life style including poor nutrition can result in imbalance in our oxidation/redox systems. Lipids can undergo oxidative modification by lipoxygenases, cyclooxygenases, myeloperoxidase, and other enzymes. Oxidized phospholipids can induce inflammatory molecules in the liver and other organs. This can contribute to inflammation, leading to coronary heart disease, stroke, renal failure, inflammatory bowl disease, metabolic syndrome, bone and joint disorders, and even certain types of cancer.Our antioxidant and antiinflammatory defense mechanisms contribute to a balance between the stimulators and the inhibitors of inflammation. Beyond a point, however, these systems might be overwhelmed and eventually fail. High-density lipoprotein is a potent inhibitor of the formation of toxic oxidized lipids. High-density lipoprotein is also an effective system for stimulating the genes whose products are active in the removal, inactivation, and elimination of toxic lipids. Supporting the high-density lipoprotein function should help maintain the balance in these systems. It is hoped that the present report would elucidate some of the ongoing work toward this goal.Keywords
This publication has 24 references indexed in Scilit:
- A treasure trove for lipoprotein biology.Nature Genetics, 2008
- Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesityProceedings of the National Academy of Sciences of the United States of America, 2007
- Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytesNature Genetics, 2007
- Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoEJCI Insight, 2007
- High-Density Lipoprotein Modulates Oxidized Phospholipid Signaling in Human Endothelial Cells From Proinflammatory to Anti-inflammatoryArteriosclerosis, Thrombosis, and Vascular Biology, 2007
- Decreased Obesity and Atherosclerosis in Human Paraoxonase 3 Transgenic MiceCirculation Research, 2007
- Serum Lipids in the GENECARD Study of Coronary Artery Disease Identify Quantitative Trait Loci and Phenotypic Subsets on Chromosomes 3q and 5qAnnals of Human Genetics, 2006
- A Role for Oxidized Phospholipids in AtherosclerosisThe New England Journal of Medicine, 2005
- Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDLJournal of Lipid Research, 2004
- Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factorsCellular Signalling, 2002