Clinical Immunity to Plasmodium falciparum Malaria Is Associated with Serum Antibodies to the 19-kDa C-Terminal Fragment of the Merozoite Surface Antigen, PfMSP-l

Abstract

The development of an effective malaria vaccine depends upon identification of antigens that are targets of protective immune responses. An immunoepidemiologic approach has been used to investigate the relationship between antibody responses to a defined region of the major merozoite surface protein of Plasmodiumjalciparum (PfMSP-1₁₉) and resistance to clinical malaria in 2 populations of children from West Africa. After allowing for the confounding effects of age, antibodies to PfMSP-1₁₉ were shown to provide ∼40% protection against clinical malaria in children in Sierra Leone.In Gambian children, antibodies to one of the epidermal growth factor-like motifs of PfMSP-1₁₉ were strongly associated with resistance to both clinical malaria and high levels of parasitemia.